Janeane Garofalo portrays Marcy Tizard, a cynical American political aide sent to Ireland to find her boss' ancestors.
David O'Hara plays Sean Kelly, a traditional Irish matchmaker who helps Marcy in her quest.
Milo O’Shea is Dermot O'Brien, the local bartender who becomes involved in the matchmaking shenanigans.
Jay O. Sanders takes on the role of Senator John McGlory, whose political future is tied to Marcy's success.
Rosaleen Linehan portrays Millie O'Dowd, a lively Irish widow who plays a key role in the matchmaking scheme.
Paul Hickey as Declan Kelly, Sean Kelly's brother who gets caught up in the matchmaking chaos.
Maria Doyle Kennedy is Sarah Kelly, Sean's wife who has her own reasons for supporting Marcy.
Saffron Burrows plays Moira Kennedy Kelly, a mysterious woman with a connection to Sean and Marcy's mission.
Denis Leary appears as Nick, an American reporter who complicates Marcy's stay in Ireland.
Olivia Caffrey as Annie, a local in the Irish village who becomes Marcy's friend during her stay.
Joan Sheehy in the role of Bus Passenger, a minor character who encounters Marcy during her travels.
Anne Gildea plays Airport Assistant, a small but memorable role in assisting Marcy's arrival in Ireland.
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