Dani Moonstar, a young Cheyenne mutant who experiences intense visions and can create illusions tied to others' fears.
Rahne Sinclair, a Scottish mutant who can transform into a wolf or wolf-like form and struggles with her religious beliefs.
Illyana Rasputin, a Russian girl with powers linked to teleportation and a shadowy other realm.
Samuel Guthrie, a patient who can propel himself through the air and generate powerful kinetic force.
Roberto da Costa, a Brazilian mutant who can absorb and release solar energy, affecting his strength and body temperature.
Dr. Reyes, a doctor who oversees the young mutants at the medical facility and works to treat and contain their abilities.
Dani's Father, the father of Dani Moonstar who appears in scenes from her life before she is brought to the facility.
Reverend Craig, a local religious leader who is connected to one of the patients' personal histories.
Smiling Man, a mysterious figure who frequently appears in the patients' visions.
Smiling Man (voice), the voice actor for the Smiling Man character heard in the film's visions.
Sam's Father, the father of Samuel Guthrie who appears in family scenes and flashbacks.
Young Illyana, a younger version of Illyana Rasputin who appears in flashbacks and memory sequences.
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