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The Substance

The Substance Cast

123 cast members · 9 with popularity data
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Most Popular The Substance Cast Members

Margaret Qualley is currently the most popular The Substance cast member online with a Attention Score of 11.3. 4 of 123 cast members rank in the top 1,000 actors online today. Updated September 14, 2026.

1
Margaret Qualley
Sue
11.3
#166 overall
2
Demi Moore
Elisabeth
5.6
#601 overall
3
Hugo Diego Garcia
Diego - Boyfriend
5.3
#668 overall
4
Dennis Quaid
Harvey
4.5
#886 overall
5
Coralie Fargeat
(uncredited)
0.5
#10,873 overall
6
Christian Erickson
Man at Diner
0.0
#41,660 overall
7
Shane Sweet
Additional Voices (voice)
0.0
#42,786 overall
8
Michael Corbett
Additional Voices (voice)
0.0
#47,992 overall
9
Aleksandra Kedzierska Fontaine
New Year's Eve Show Dancer
0.0
#63,214 overall
10
Edward Hamilton-Clark
Fred
—
11
Gore Abrams
Oliver
—
12
Oscar Lesage
Troy
—
13
Robin Greer
Male Nurse
—
14
Jiselle Burkhalter
Girl
—
15
Tom Morton
Doctor
—
16
Daniel Knight
Casting Director
—
17
Jonathon Carley
Assistant Casting Director
—
18
Matthew Géczy
Bob Haswell
—
19
Jiselle Henderkott
Girl Auditioning / New Year's Eve Show Dancer
—
20
Akil Wingate
TV Host
—
21
Namory Bakayoko
Silhouette
—
22
Vincent Colombe
Man in Suit #1 - Harvey's Office
—
23
Billy Bentley
Man in Suit #2
—
24
Bill Bentley
Suit
—
25
Lucie Laffin
Woman from the Public
—
26
Lennard Ridsdale
Man in Suit #3
—
27
Gregory Defleur
Happy Birthday Person
—
28
Jordan Ford Silver
Assistant Director - Pump It Up Show
—
29
Oscar Salem
2nd Assistant Director - Pump It Up Show
—
30
Viviane Bossina
Sue's Assistant
—
31
Matthew Luret
Floor Runner
—
32
Jana Bittnerová
Maria
—
33
Olivier Raynal
Alan - 2nd Agent
—
34
Tiffany Hofstetter
Stylist
—
35
Nicolas Royer
Guy in the Elevator
—
36
Nathan Rippy
Assistant Director - New Year's Eve Show
—
37
Manon Arizmendi
Little Girl - New Year's Eve Show
—
38
Virginie Kotlinski
Mother - New Year's Eve Show
—
39
Brett Gillen
Director of Photography - New Year's Eve Show
—
40
Charlotte Marquardt
Screaming Woman
—
41
Léa Hengl
Screaming Woman
—
42
Gaëlle Raymond
Screaming Woman
—
43
Claire Lemaire
Screaming Woman
—
44
Lila Boughoufala
Screaming Woman
—
45
Aurélien Lorgnier
Screaming Man
—
46
Ivan Sellier
Screaming Man
—
47
Philip Schurer
Screaming Man
—
48
Christian Bourmier
Shareholder
—
49
Martin Graham
Shareholder
—
50
Christian Bordeleau
Shareholder
—
51
Patrick Hamel
Shareholder
—
52
Didier Dhondt
Shareholder
—
53
Jacques-Yves Dorges
Shareholder
—
54
Jean-Claude Matthey
Shareholder
—
55
Olivier Jarcin
Shareholder
—
56
Jean-Luc Magneron
Shareholder
—
57
Charlotte Murray
Allison - Diner Waitress
—
58
Aaron Kahn
Greeting Person
—
59
Gabriela Arnon
Greeting Person
—
60
Nancy Josephson Lahoussine
Greeting Person
—
61
Andrew Eldridge
Greeting Person
—
62
Denise Powers
Greeting Person
—
63
Bryan Jones
Greeting Person
—
64
Adam Carage
Happy Birthday Person
—
65
Maria McClurg
Happy Birthday Person
—
66
Andrew Desmond
Happy Birthday Person
—
67
Rebecca Lafont
Happy Birthday Person
—
68
Laura Puech
Isabella
—
69
Ryan Chidester
Stagehand
—
70
Cécile Vogt
Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer
—
71
Yannick Guérin
Clumsy Burger Guy - Walk of Fame
—
72
Jean Miel
Worker Walk of Fame
—
73
Paul Descoings
Worker Walk of Fame
—
74
Benoit Lévêque
Worker Walk of Fame
—
75
Arthur Molinet
Cocktail Bartender
—
76
Manon Sachot
Cocktail Lounge Couple
—
77
Bastien Jorelle
Cocktail Lounge Couple
—
78
Kelly Hoarau
Female Assistant - Towel
—
79
Michel Juskiewicz
George - Harvey's Friend
—
80
Louise Greggory
Restaurant Waitress
—
81
Christophe Sartirano
Guy Looking at Sue
—
82
Florent Torres
Guy Looking at Sue
—
83
Romain Caldeira
Billboard Technician
—
84
Barthelemy Thomas
Billboard Technician
—
85
Axel Baille
Photographer
—
86
Ashley Lambert
Additional Voices (voice)
—
87
Ranjani Brow
Additional Voices (voice)
—
88
Chase Fein
Additional Voices (voice)
—
89
William Calvert
Additional Voices (voice)
—
90
Stephen Apostolina
Additional Voices (voice)
—
91
Yann Bean
The Substance (voice)
—
92
Audjyan Alcide
Pump It Up Show Dancer
—
93
Jonathan Jenvrin
Pump It Up Show Dancer
—
94
Mimi Maury
Pump It Up Show Dancer
—
95
Amelye Solange
Pump It Up Show Dancer
—
96
Kévin Table
Pump It Up Show Dancer
—
97
Laura Boera
Sparkle Your Life Show Dancer
—
98
Cissy Duc
Sparkle Your Life Show Dancer
—
99
Sophie Mercier
Sparkle Your Life Show Dancer
—
100
Marie Valton
Sparkle Your Life Show Dancer
—
101
Katrina Budzynski
New Year's Eve Show Dancer
—
102
Alicia Maury
New Year's Eve Show Dancer
—
103
Megane Adamik
New Year's Eve Show Dancer
—
104
Annalisa Pagnotta
New Year's Eve Show Dancer
—
105
Maelle Dantigny
New Year's Eve Show Dancer
—
106
Pauline Sagetat
New Year's Eve Show Dancer
—
107
Agustina Fitzsimons
New Year's Eve Show Dancer
—
108
Elena Shcheglova
New Year's Eve Show Dancer
—
109
Eve Marchant
New Year's Eve Show Dancer
—
110
Lola Donati
New Year's Eve Show Dancer
—
111
Kate Matthews
New Year's Eve Show Dancer
—
112
Ophélie Jonard
New Year's Eve Show Dancer
—
113
Pauline Richard
New Year's Eve Show Dancer
—
114
Laureen Cappelliez
New Year's Eve Show Dancer
—
115
Daria Panchenko
New Year's Eve Show Dancer
—
116
Delphine Beaulieu
New Year's Eve Show Dancer
—
117
Victoria Brun
New Year's Eve Show Dancer
—
118
Cara Chapman
New Year's Eve Show Dancer
—
119
Katharine Matthews
New Year's Eve Show Dancer
—
120
Alexandra Faget
New Year's Eve Show Dancer
—
121
Clémence Juville
New Year's Eve Show Dancer
—
122
Margot L'Entete
New Year's Eve Show Dancer
—
123
Hillary Sukhonos
New Year's Eve Show Dancer
—
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