An American Werewolf in London

David Naughton plays the lead role of David Kessler, an American tourist who survives a werewolf attack and becomes a werewolf himself.

Jenny Agutter portrays Nurse Alex Price, who takes care of David Kessler and later becomes romantically involved with him.

Griffin Dunne plays Jack Goodman, David's friend who dies in the werewolf attack but continues to appear to David as an undead spirit.

John Woodvine portrays Dr. J. S. Hirsch, a skeptical doctor treating David Kessler after the werewolf attack.

Don McKillop appears as Inspector Villiers, a police officer investigating the mysterious deaths in the film.

Brian Glover plays the Chess Player in a pub scene where locals discuss the werewolf sightings.

David Schofield portrays the Dart Player in the same pub scene where the Chess Player appears.

Lila Kaye plays the Barmaid in the pub scene, interacting with the other characters.

Rik Mayall makes a brief appearance as the 2nd Chess Player in the pub scene.

Sean Baker appears as the 2nd Dart Player in the pub, joining the conversation about the werewolf.

Frank Oz provides the voice for Mr. Collins / Miss Piggy in archival footage shown in the film.

Paul Kember plays Sergeant McManus, one of the police officers involved in the investigation of the werewolf incidents.