Mickey Rourke plays Harry Angel, a private investigator hired to track down a missing crooner.
Robert De Niro portrays Louis Cyphre, a mysterious and enigmatic client who hires Harry Angel for a questionable job.
Lisa Bonet stars as Epiphany Proudfoot, a young woman caught up in the dark and supernatural events surrounding Harry Angel's investigation.
Charlotte Rampling appears as Margaret Krusemark, a key figure with a connection to the missing crooner and a mysterious past.
Stocker Fontelieu portrays Ethan Krusemark, a character intertwined with the dark secrets Harry Angel uncovers.
Brownie McGhee plays Toots Sweet, a blues guitarist who aids Harry Angel in his investigation.
Michael Higgins is Doctor Fowler, a physician involved in the eerie events surrounding Harry Angel's case.
Elizabeth Whitcraft appears as Connie, a character with ties to the missing crooner's past.
Eliott Keener portrays Sterne, a mysterious figure who becomes entangled in Harry Angel's search for the truth.
Charles Gordone plays Spider Simpson, a key player in the dark and intricate web of deceit that Harry Angel uncovers.
Dann Florek is Winesnap, a character who adds to the suspense and intrigue surrounding Harry Angel's investigation.
Kathleen Wilhoite appears as the Nurse, a character who plays a part in the unfolding mystery of Angel Heart.
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