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Marisa Abela portrays Amy Winehouse, focusing on the singer's tumultuous journey through the music industry and her personal life.

Jack O'Connell embodies Blake Fielder-Civil, Amy's ex-husband, known for his tumultuous relationship with the artist.

Eddie Marsan plays Mitch Winehouse, depicting Amy's father and his influence on her life and career.

Lesley Manville takes on the role of Cynthia Winehouse, Amy's dependable and caring grandmother.

Juliet Cowan is cast as Janis Winehouse-Collins, portraying Amy's mother and her part in Amy's life story.

Sam Buchanan plays Nick Shymansky, Amy's friend and first manager who witnessed her early career development.

Michael S. Siegel portrays Uncle Harold, a family member in Amy's close-knit circle.

Matilda Thorpe plays Aunt Melody, a relative who provides support in the depiction of Amy's family background.

Ryan O'Doherty brings to life Chris Taylor, a character involved in the narrative of Amy's life.

Harley Bird takes on the role of Juliette, a fictional character in the film who interacts with Amy's storyline.

Bronson Webb appears as Joey, one of the individuals in Amy's life, contributing to the narrative of her story.

Ansu Kabia portrays Raye Cosbert, Amy's manager who played a significant role in her professional journey.