Johnny Depp plays Sam, a free-spirited and eccentric young man who befriends Joon and brings a sense of whimsy and joy into her life.
Mary Stuart Masterson portrays Juniper 'Joon' Pearl, a creative and mentally ill young woman who forms a unique and special bond with Sam.
Aidan Quinn takes on the role of Benjamin 'Benny' Pearl, Joon's overprotective older brother who struggles to balance caring for his sister and living his own life.
Julianne Moore appears as Ruthie, a quirky and caring friend who only wants the best for Benny and Joon.
Oliver Platt plays Eric, a kind and supportive friend of Benny who offers a helping hand whenever needed.
CCH Pounder portrays Dr. Garvey, a compassionate and understanding psychiatrist who helps Benny and Joon navigate their challenges.
Dan Hedaya appears as Thomas, a concerned and practical mechanic who interacts with the quirky trio.
Joe Grifasi takes on the role of Mike, a friend of Benny who provides a sense of humor and support.
William H. Macy portrays Randy Burch, a quirky but well-meaning individual who crosses paths with the main characters.
Liane Curtis appears as Claudia, a friend who offers a glimpse into the outside world for Benny and Joon.
Eileen Ryan plays Mrs. Smail, a neighbor who adds a touch of realism to the characters' lives.
Lynette Walden portrays Female Customer, a brief but memorable role that adds a touch of humor to the story.
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