Eddie Murphy plays the lead role of Prince Akeem, a charming and wealthy African prince who travels to America in search of true love. He also takes on the roles of Clarence, Randy Watson, and Saul in the movie.
Arsenio Hall portrays Semmi, Prince Akeem's loyal friend and servant, who accompanies him on his journey. He also takes on the roles of Extremely Ugly Girl, Morris, and Reverend Brown.
James Earl Jones appears as King Jaffe Joffer, Prince Akeem's wise and dignified father and the ruler of Zamunda.
John Amos plays the role of Cleo McDowell, the owner of McDowell's fast-food restaurant in Queens where Akeem works.
Shari Headley portrays Lisa McDowell, the independent and intelligent daughter of Cleo McDowell, who captures Prince Akeem's heart.
Frankie Faison appears as the Landlord who owns the apartment building where Akeem and Semmi reside in Queens.
Louie Anderson plays the role of Maurice, a friendly employee at McDowell's restaurant who befriends Prince Akeem.
Eriq La Salle portrays Darryl Jenks, Lisa's arrogant and wealthy boyfriend who becomes a rival to Prince Akeem.
Allison Dean appears as Patrice McDowell, Lisa's supportive and caring sister.
Madge Sinclair appears as Queen Aoleon, King Jaffe's elegant and supportive wife.
Paul Bates portrays Oha, Prince Akeem's loyal royal servant and friend.
Samuel L. Jackson makes a brief appearance as the Hold-Up Man who attempts to rob McDowell's restaurant.
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