Sigourney Weaver plays Helen Hudson, a psychologist and expert on serial killers who becomes a target of a copycat killer.
Holly Hunter portrays M.J. Monahan, a detective who partners with Helen Hudson to catch a copycat killer.
Dermot Mulroney appears as Ruben Goetz, a friend of Helen Hudson who becomes involved in the investigation.
William McNamara plays Peter Foley, a key character connected to the copycat killer case.
Harry Connick Jr. portrays Daryll Lee Cullum, a menacing figure linked to the crimes.
J.E. Freeman appears as Lt. Quinn, a law enforcement officer involved in the investigation.
Will Patton plays Nicoletti, another member of the law enforcement team working on the case.
John Rothman appears as Andy, a character involved in the unfolding events.
Shannon O'Hurley portrays Susan Schiffer, a character impacted by the copycat killer.
Bob Greene appears as Pachulski, a member of the investigating team.
Tony Haney plays Kerby, adding to the ensemble of characters involved in the case.
Danny Kovacs appears as Kostas, contributing to the unfolding narrative of Copycat.
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