Kiefer Sutherland plays Nelson Wright, a medical student who leads the group in conducting dangerous experiments involving near-death experiences.
Julia Roberts portrays Rachel Mannus, a medical student who becomes deeply involved in the experimental procedures with her colleagues.
Kevin Bacon takes on the role of David Labraccio, a member of the medical student group who participates in the near-death experience research.
William Baldwin plays Joe Hurley, one of the medical students who joins in the risky experiments to explore the mysteries of death and the afterlife.
Oliver Platt portrays Randy Steckle, a member of the group of medical students who partake in the dangerous experiments to uncover the unknown.
Kimberly Scott appears as Winnie Hicks, a character involved in the medical student group's controversial study on near-death experiences.
Joshua Rudoy plays Billy Mahoney, a character connected to the medical student group investigating the boundaries between life and death.
Benjamin Mouton portrays Rachel's Father, a figure possibly affected by the consequences of his daughter's involvement in the near-death experience experiments.
Aeryk Egan takes on the role of Young Nelson, depicting the character of Nelson Wright during earlier years, shedding light on his background.
Kesha Reed appears as Young Winnie, showcasing the character of Winnie Hicks during her earlier years as part of the medical student group.
Hope Davis plays Anne Coldren, a character entangled in the repercussions of the medical students' risky experiments involving near-death experiences.
Jim Ortlieb portrays Uncle Dave, a character connected to the events surrounding the medical students' exploration of the afterlife through near-death experiences.
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