Ben Stiller plays Mel Coplin, a neurotic new father who goes on a quest to find his birth parents.
Patricia Arquette portrays Nancy Coplin, Mel's supportive wife who joins him on his quest.
Téa Leoni plays Tina Kalb, an adoption agent who helps Mel search for his biological parents.
Mary Tyler Moore portrays Pearl Coplin, Mel's adoptive mother, who is skeptical of his journey.
George Segal plays Ed Coplin, Mel's adoptive father who has his own secrets.
Alan Alda portrays Richard Schlichting, one of the potential biological parents Mel visits.
Lily Tomlin plays Mary Schlichting, Richard's wife who has her own quirks.
Richard Jenkins portrays Paul Harmon, a friend of Mel's who inadvertently complicates the journey.
Josh Brolin plays Tony Kent, another potential biological parent in Mel's search.
Celia Weston portrays Valerie Swaney, a woman Mel suspects may be his birth mother.
Glenn Fitzgerald plays Lonnie Schlichting, the son of the potential birth parents Mel visits.
Beth Stern portrays Jane, a woman Mel encounters during his search for his parents.
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