Bill Murray provides the voice for Garfield, a lazy but witty orange tabby cat who loves lasagna.
Breckin Meyer portrays Jon Arbuckle, Garfield's bumbling but caring owner.
Jennifer Love Hewitt plays Liz Wilson, Jon's kind and supportive veterinarian love interest.
Stephen Tobolowsky portrays Happy Chapman, the greedy and conniving television host.
Evan Arnold appears as Wendell, Jon's easygoing and supportive friend.
Mark Christopher Lawrence plays the role of Christopher Mello, one of Garfield's fellow animals.
Jimmy Kimmel voices Spanky, a mischievous and funny mouse friend of Garfield.
Debra Messing provides the voice for Arlene, Garfield's sassy and confident cat friend.
Nick Cannon voices Louis, a streetwise and cool rat who befriends Garfield.
Alan Cumming voices Persnikitty, a sophisticated and artistic Persian cat friend of Garfield.
Brad Garrett voices Luca, a tough but lovable dog who is part of Garfield's group of friends.
David Eigenberg provides the voice for Nermal, the adorable but sometimes annoying kitten friend of Garfield.
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