Matthew Modine plays Joe Slovak, a medical student whose unorthodox behavior and bold personality sometimes clash with the seriousness of his academic pursuits.
Daphne Zuniga portrays Laurie Rorbach, another medical student with a strong work ethic who forms a complex relationship with Joe Slovak.
In the role of Dr. Rachel Woodruff, Christine Lahti plays a dedicated and respected professor who challenges her students both academically and personally.
Todd Field portrays David Schreiner, a fellow medical student who becomes a close friend to Joe Slovak and shares in the trials and triumphs of their first year.
John Scott Clough plays Miles Reed, another medical student in the group who brings his own unique perspective and experiences to the challenges they face.
As Kim McCauley, Alice Carter portrays a medical student who must balance her personal life with the demands of her studies alongside Joe Slovak and his peers.
Robert Desiderio takes on the role of Dr. Banks, a faculty member at the medical school who provides guidance and mentorship to the students.
Zakes Mokae portrays Dr. Banumbra, another faculty member who challenges the students with his teachings and expectations throughout the movie.
Clyde Kusatsu appears as one of the Interviewing Professors, contributing to the academic evaluation and growth of the medical students in the film.
John Petlock plays an Interviewing Professor who plays a role in assessing the progress and skills of the medical students throughout the movie.
J. Patrick McNamara portrays an Interviewing Professor who takes part in the evaluation process of the medical students, offering insight and feedback.
In Gross Anatomy, Jan Munroe appears as an Interviewing Professor, playing a part in the academic journey and challenges faced by the medical students.
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