Craig Sheffer plays Aaron Boone, the protagonist who seeks refuge with the Nightbreed, a community of monsters hiding from humanity.
Anne Bobby portrays Lori Desinger, Boone's girlfriend who becomes involved in the supernatural world of the Nightbreed.
David Cronenberg takes on the role of Dr. Philip K. Decker, a psychiatrist with a dark secret who manipulates Boone.
Charles Haid plays Captain Eigerman, a police officer who pursues the Nightbreed community with a ruthless determination.
Hugh Quarshie portrays Detective Joyce, a detective investigating Boone's case and uncovering the truth about the Nightbreed.
Hugh Ross plays Narcisse, a member of the Nightbreed with a complex past and unique abilities.
Doug Bradley embodies Dirk Lylesberg, a charismatic member of the Nightbreed with a mysterious allure.
Catherine Chevalier portrays Rachel, a member of the Nightbreed who forms a connection with Boone.
Malcolm Smith plays Ashberry, a member of the Nightbreed known for his fierce loyalty and protective nature.
Bob Sessions portrays Pettine, a human ally of the Nightbreed who supports their struggle against the authorities.
Oliver Parker takes on the role of Peloquin, a powerful and enigmatic member of the Nightbreed with a primal nature.
Debora Weston plays Sheryl Ann, a human character who becomes entangled in the conflict between the Nightbreed and humanity.
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