Jared Leto plays the titular character, Steve Prefontaine, an influential American long-distance runner known for his talent and outspoken attitude.
R. Lee Ermey portrays Bill Bowerman, the legendary coach who co-founded Nike and coached Prefontaine during his career.
Ed O'Neill takes on the role of Bill Dellinger, a respected coach and former Olympian who played a significant part in Prefontaine's development.
Breckin Meyer portrays Pat Tyson, a key figure in Prefontaine's life as a coach and mentor who influenced his approach to running.
Lindsay Crouse plays Elfriede Prefontaine, Steve's mother who supported and encouraged him throughout his running career.
Amy Locane portrays Nancy Alleman, a significant person in Prefontaine's life who played a role in shaping his personal life.
Laurel Holloman takes on the role of Elaine Finley, a character closely connected to Prefontaine and his journey in the film.
Brian McGovern plays Mac Wilkins, an athlete and character who interacts with Prefontaine during his journey in the film.
Kurtwood Smith portrays Curtis Cunningham, a character who contributes to the narrative of Prefontaine's life in the movie.
Adrian Amadeus plays the Finnish Teammate, a character who adds an international perspective to Prefontaine's story.
Laurence Ballard portrays O'Hara, a character with a role in the unfolding events surrounding Steve Prefontaine.
Ryan Brewer plays the 12 Year Old Kid, a brief but memorable character part of Steve Prefontaine's journey in the film.
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