Christine Lahti portrays Annie Pope, a devoted mother who has spent years on the run with her family to avoid arrest for their anti-war activities.
River Phoenix plays Danny Pope, the son of Annie and Arthur Pope, struggling with his desire for a normal life while torn between loyalty to his family and pursuing his aspirations.
Judd Hirsch takes on the role of Arthur Pope, a former radical activist who continues to be hunted by the FBI for his involvement in a politically motivated bombing.
Martha Plimpton portrays Lorna Phillips, a high school student who becomes romantically involved with Danny Pope, sparking conflicts within the Pope family.
L.M. Kit Carson plays Gus Winant, a friend of the Pope family who tries to help them as they navigate their fugitive lifestyle.
Steven Hill portrays Donald Patterson, a former colleague of Arthur Pope who inadvertently discovers the Pope family's true identities, leading to a series of events.
Augusta Dabney takes on the role of Abigail Patterson, the wife of Donald Patterson, who gets embroiled in the consequences of her husband's actions regarding the Pope family.
David Margulies plays Dr. Jonah Reiff, a sympathetic physician who becomes entwined in the Pope family's struggles as they try to maintain their underground existence.
Lynne Thigpen appears as a Contact at Eldridge St., a mysterious figure who provides assistance to the Pope family in their attempts to remain hidden from authorities.
Marcia Jean Kurtz portrays a School Clerk, a minor character who has a brief interaction with the Pope family, adding to the tension of their fugitive lifestyle.
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