Cast of Scream 4

David Arquette reprises his role as Dewey Riley, now the sheriff of Woodsboro, who is once again drawn into a series of chilling murders.

Neve Campbell returns as Sidney Prescott, the resilient survivor of the Ghostface killings, who becomes a target yet again upon her return to her hometown.

Courteney Cox embodies Gale Weathers-Riley, a tenacious journalist and wife of Dewey, struggling with writer's block and a desire to solve the new murders.

Emma Roberts plays Jill Roberts, Sidney Prescott's cousin, who finds herself at the center of the new Ghostface's deadly games.

Hayden Panettiere portrays Kirby Reed, a quick-witted and resourceful high school student with an extensive knowledge of horror movie trivia.

Anthony Anderson takes on the role of Deputy Perkins, one of the deputies working under Sheriff Dewey Riley in the troubled town of Woodsboro.

Adam Brody appears as Deputy Hoss, another member of the Woodsboro law enforcement team investigating the new series of murders.

Rory Culkin plays Charlie Walker, a film enthusiast and high school student who finds himself involved in the murders.

Mary McDonnell is Kate Roberts, the mother of Jill Roberts and aunt to Sidney Prescott, dealing with the return of Ghostface.

Marley Shelton portrays Deputy Judy Hicks, a Woodsboro deputy with a hidden past connection to Sidney Prescott.

Alison Brie plays Rebecca Walters, Sidney Prescott's ambitious publicist who gets caught up in the killer's deadly schemes.

Marielle Jaffe appears as Olivia Morris, one of Jill's friends in high school and another potential victim of the new Ghostface.