Splice Cast
The cast of Splice including popularity data. Data for February 22, 2025.
Adrien Brody
as Clive

Adrien Brody plays Clive Nicoli, a skilled genetic engineer who co-leads the controversial experiment to create a new life form.

#1
Most popular actor on Splice
16,870 Wikipedia views yesterday
Sarah Polley
as Elsa

Sarah Polley portrays Elsa Kast, an ambitious geneticist who partners with Clive in conducting their groundbreaking work.

#2
Most popular actor on Splice
1,002 Wikipedia views yesterday
Delphine Chanéac
as Dren

Delphine Chanéac takes on the role of Dren, the humanoid creature resulting from the splicing experiment.

David Hewlett
as Barlow

David Hewlett appears as Barlow, a colleague of the scientist protagonists Clive and Elsa.

#4
Most popular actor on Splice
353 Wikipedia views yesterday
Abigail Chu
as Young Dren

Abigail Chu plays the younger version of Dren, providing insight into the early stages of the creature's life.

Stephanie Baird
as Elsa / PD

Stephanie Baird is cast as Elsa / PD, giving a performance connected to the character Elsa Kast.

Brandon McGibbon
as Gavin

Brandon McGibbon features as Gavin, taking up a secondary role within the story's unfolding events.

Amanda Brugel
as Melinda Finch

Amanda Brugel fills the role of Melinda Finch, one of the characters that interact with the main protagonists in the film.

#3
Most popular actor on Splice
412 Wikipedia views yesterday
Simona Măicănescu
as Joan Chorot

Simona Măicănescu plays Joan Chorot, a part of the cast that supports the central narrative of the film.

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