Cast of Splice

Adrien Brody plays Clive Nicoli, a skilled genetic engineer who co-leads the controversial experiment to create a new life form.

Sarah Polley portrays Elsa Kast, an ambitious geneticist who partners with Clive in conducting their groundbreaking work.

Delphine Chanéac takes on the role of Dren, the humanoid creature resulting from the splicing experiment.

David Hewlett appears as Barlow, a colleague of the scientist protagonists Clive and Elsa.

Abigail Chu plays the younger version of Dren, providing insight into the early stages of the creature's life.

Stephanie Baird is cast as Elsa / PD, giving a performance connected to the character Elsa Kast.

Brandon McGibbon features as Gavin, taking up a secondary role within the story's unfolding events.

Amanda Brugel fills the role of Melinda Finch, one of the characters that interact with the main protagonists in the film.

Simona Măicănescu plays Joan Chorot, a part of the cast that supports the central narrative of the film.