Helen Slater plays Kara Zor-El, a Kryptonian who comes to Earth and becomes the superhero Supergirl.
Faye Dunaway portrays Selena, the villainous sorceress who opposes Supergirl.
Peter O'Toole takes on the role of Zaltar, a mentor figure to Supergirl.
Hart Bochner plays Ethan, a love interest of Supergirl.
Mia Farrow portrays Alura, Kara Zor-El's Kryptonian mother.
Brenda Vaccaro plays Bianca, Selena's confidante and ally.
Peter Cook portrays Nigel, Selena's bumbling assistant.
Simon Ward plays Zor-El, Kara Zor-El's father from Krypton.
Marc McClure portrays Jimmy Olsen, a photographer at the Daily Planet.
Maureen Teefy plays Lucy Lane, the sister of Lois Lane and friend of Supergirl.
David Healy portrays Mr. Danvers, a teacher at Midvale School.
Matt Frewer plays Eddie, a truck driver who encounters Supergirl.
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