Cast of The Guilt Trip

The Guilt Trip features a talented cast bringing the characters to life. Seth Rogen plays the role of Andy Brewster, while Barbra Streisand portrays Joyce Brewster. Yvonne Strahovski takes on the character of Jessica, Colin Hanks as Rob, Brett Cullen as Ben, Adam Scott as Andrew Margolis Jr., Ari Graynor as Joyce Margolis, and Kathy Najimy as Gayle. The most popular cast member today is Seth Rogen, Andy Brewster.