Robert Duvall portrays Gruen, a character involved in the pursuit of D.B. Cooper.
Treat Williams plays the titular role of D.B. Cooper, the infamous hijacker who pulls off a daring heist.
Kathryn Harrold portrays Hannah, a character caught up in the mystery surrounding D.B. Cooper.
Ed Flanders plays Brigadier, a character involved in the investigation of the D.B. Cooper case.
Paul Gleason portrays Remson, a character connected to the events surrounding D.B. Cooper.
R. G. Armstrong plays Dempsey, a character entangled in the aftermath of D.B. Cooper's heist.
Dorothy Fielding portrays Denise, a character involved in the unfolding drama of D.B. Cooper's escape.
Howard K. Smith makes an appearance in his own role as a news anchor covering the D.B. Cooper story.
John Richard Petersen appears as Paramedic in an uncredited role in the movie.
Karen Newhouse appears as Girl Friend in Stream, a minor character in The Pursuit of D.B. Cooper.
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