You, Me and Dupree Cast
The cast of You, Me and Dupree including popularity data. Data for March 28, 2025.
Owen Wilson
as Dupree

Portrayed the character Dupree.

#5
Most popular actor on You, Me and Dupree
4,226 Wikipedia views yesterday
Kate Hudson
as Molly

Portrayed the character Molly.

#2
Most popular actor on You, Me and Dupree
11,699 Wikipedia views yesterday
Matt Dillon
as Carl

Portrayed the character Carl.

#6
Most popular actor on You, Me and Dupree
3,303 Wikipedia views yesterday
Michael Douglas
as Mr. Thompson

Portrayed the character Mr. Thompson.

#3
Most popular actor on You, Me and Dupree
7,694 Wikipedia views yesterday
Seth Rogen
as Neil

Portrayed the character Neil.

#1
Most popular actor on You, Me and Dupree
26,323 Wikipedia views yesterday
Amanda Detmer
as Annie

Portrayed the character Annie.

#12
Most popular actor on You, Me and Dupree
294 Wikipedia views yesterday
Bill Hader
as Mark

Portrayed the character Mark.

#7
Most popular actor on You, Me and Dupree
3,087 Wikipedia views yesterday
Todd Stashwick
as Tony

Portrayed the character Tony.

#11
Most popular actor on You, Me and Dupree
380 Wikipedia views yesterday
Ralph Ting
as Toshi
Lance Armstrong
as Self
#4
Most popular actor on You, Me and Dupree
4,294 Wikipedia views yesterday
Suzanne Ford
as Thompson's Secretary
Claudia Choi
as Carl's Secretary
Eli Vargas
as Aaron
Amber Hay
as Wedding Guest (uncredited)
Harry Dean Stanton
as Curly (uncredited)
#8
Most popular actor on You, Me and Dupree
1,888 Wikipedia views yesterday
Jason Winer
as Eddie
Sidney S. Liufau
as Paco
#16
Most popular actor on You, Me and Dupree
21 Wikipedia views yesterday
Billy Gardell
as Bartender Dave
#10
Most popular actor on You, Me and Dupree
911 Wikipedia views yesterday
Houston Mack
as Dougie
Bob Larkin
as Army Veteran
#17
Most popular actor on You, Me and Dupree
10 Wikipedia views yesterday
Summer Altice
as Stripper
#14
Most popular actor on You, Me and Dupree
75 Wikipedia views yesterday
Jeanine Hass
as Stripper
Peter Ruocco
as Wedding Planner
Joe Russo
as Personnel Manager
Lance Irwin
as Neighborhood Father
Fenessa Pineda
as 2nd Grade Girl
#15
Most popular actor on You, Me and Dupree
32 Wikipedia views yesterday
Mario Revolori
as 2nd Grade Boy
Jay Lembeck
as Minister
Gil Harris
as Reese
Pat Crawford Brown
as Aunt Kathy
#13
Most popular actor on You, Me and Dupree
94 Wikipedia views yesterday
Bayani Ison
as Hawaiian Bartender
Joe Wilson
as Joe
Blaine Pate
as Larry
Kevin Breznahan
as Charlie
Trevor Stock
as Herb
Sean Perrone
as Ned
Craig Hosking
as Pilot
Kepa Kruse
as Waiter (uncredited)
Michelle Lee
as Hawaiian Air Ticketing Agent (uncredited)
May Porter
as Waitress (uncredited)
Tasha Smith
as Co-Worker (uncredited)
#9
Most popular actor on You, Me and Dupree
1,458 Wikipedia views yesterday
For the best insights and data about You, Me and Dupree, visit our main You, Me and Dupree page.