A.P. Bio (TV) Cast
The cast of A.P. Bio. Updated on August 14, 2025.
146 actors
Glenn Howerton
as Jack Griffin (42 episodes)

Glenn Howerton plays Jack Griffin, an ex-philosophy professor who teaches A.P. Bio.

Lyric Lewis
as Stef (42 episodes)

Lyric Lewis portrays Stef, one of the enthusiastic teachers at Whitlock High School.

Mary Sohn
as Mary (42 episodes)

Mary Sohn plays Mary, a high-spirited teacher at the school.

Jean Villepique
as Michelle (42 episodes)

Jean Villepique is Michelle, another vibrant teacher at Whitlock High.

Tom Bennett
as Miles (13 episodes)

Tom Bennett takes on the role of Miles, Jack's rival.

Patton Oswalt
as Principal Durbin (42 episodes)

Patton Oswalt is Principal Durbin, the well-meaning principal of Whitlock High.

Aparna Brielle
as Sarika (42 episodes)

Aparna Brielle plays Sarika, a brilliant student in Jack's class.

Sari Arambulo
as Grace (42 episodes)

Sari Arambulo portrays Grace, a student in the A.P. Bio class.

Paula Pell
as Helen Henry Demarcus (37 episodes)

Paula Pell plays Helen Henry Demarcus, the secretary at Whitlock High.

Niecy Nash-Betts
as Kim (1 episode)
Ronnie Alvarez
as Waiter (1 episode)

Ronnie Alvarez appears as the Waiter.

Tim Heidecker
as Greg Miller (1 episode)

Tim Heidecker plays Greg Miller.

Taran Killam
as Mr. Vining (1 episode)
Saidah Arrika Ekulona
as School Board Beth (1 episode)
Mark Proksch
as Philip (1 episode)
Tim Lounibos
as Cliff (1 episode)
Nikki Glaser
as Chloe (1 episode)
Eden Riegel
as Katie (1 episode)
Kalpana Pot
as Nice Woman #2 (1 episode)
Rheagan Wallace
as Nice Woman #1 (1 episode)
Emily Tuñon
as Vicky (1 episode)
Kelli Dawn Hancock
as Bartender (1 episode)
Stanley Ullman
as Bus Driver (1 episode)
Erinn Hayes
as Trish (1 episode)
Lisa Loeb
as Lisa Loeb (1 episode)
Anjali Bhimani
as Sarika's Mom (1 episode)
Lori Alan
as Didi (2 episodes)
Rebecca Sohn
as Prude Mom (1 episode)
Dominique Morton
as Angry Student (1 episode)
Steve Jones
as Steve Jones (1 episode)
Bill Nye
as Bill Nye (1 episode)
Flavor Flav
as Flavor Flav (1 episode)
Will Greenberg
as Dave Eggleston (1 episode)
Jonathan T. Floyd
as Repairman (1 episode)
Eric Normington
as Publishing Executive (1 episode)
Andrew Hansen
as Tech Guy (1 episode)
Mike O'Gorman
as Chase (1 episode)
Clayton English
as David (1 episode)
Jason Huber
as Victor's Dad (1 episode)
Samantha Follows
as Victor's Mom (1 episode)
Michael Gross
as Brandon (1 episode)
Tricia O'Kelley
as Sadie (1 episode)
Collette Wolfe
as Meredith (3 episodes)
Angela Kinsey
as Brenda (1 episode)
Zach Reino
as Chops (1 episode)
Kaison Prince William
as Jeffy (1 episode)
Brianne Tju
as Dallas (1 episode)
John D'Aquino
as Dean Warren Richardson (1 episode)
Xander Evans
as Russian Student (1 episode)
Jane Morris
as Rhonda (1 episode)
Tate Birchmore
as Young Jack (1 episode)
Susan James Berger
as Dollhouse Lady (1 episode)
Hadiyah Robinson
as Mrs. Baxter (1 episode)
Jon Lovitz
as Robin Schwonk (1 episode)
Sohm Kapila
as Meena (1 episode)
Matthew Campbell Dowling
as Waiter (1 episode)
Hans Holsen
as Ron (1 episode)
Bryan Michael Nunez
as Travis (1 episode)
Marina Shtoda
as Dale's Wife (1 episode)
Cullen G. Chambers
as Mr. On-Your-Left (1 episode)
Laird Macintosh
as Mark (1 episode)
Maria Christina Thayer
as Molly (1 episode)
Denisse Ojeda
as Erica (1 episode)
Jill Czarnowski
as Mom (1 episode)
Gilbert James Talbot
as Don Chacho (1 episode)
Ruben Dario
as Dad (1 episode)
Aidan Bertola
as Kid (1 episode)
Kellee Stewart
as Marjorie (1 episode)
Karly Rothenberg
as Agatha (1 episode)
Kendra Munger
as Dr. Gordon (1 episode)
Ron Funches
as Hans (2 episodes)
Lilián García
as Ring Announcer (1 episode)
Jordan Ghaim
as Fanatic #1 (1 episode)
Calder Holbrook
as Fanatic #2 (1 episode)
Aron Stevens
as Tennessee Ronnie Log (1 episode)
Elizabeth Guest
as Gretchen (1 episode)
Rick Overton
as House Father (1 episode)
Pat McNeely
as Mrs. Goodman (1 episode)
Ed Taylor
as Bearded Man (1 episode)
Micaela Wittman
as Teenage Girl (1 episode)
Hope Shapiro
as Caleb's Mother (1 episode)
Elizabeth Phoenix Caro
as Young Girl (1 episode)
David Gborie
as Mr. McKinnon (1 episode)
Jessica Garza
as Mia Nunez (1 episode)
Cheryl Lynn Bowers
as Rosemary Griffin (3 episodes)
Douglas Bennett
as Bob (Jug Band Member) (1 episode)
John Pirruccello
as Principal Kling (1 episode)
Clint Culp
as Construction Worker (1 episode)
Meagen Fay
as Sister Frances (1 episode)
Nancy Friedrich
as Sister Monica (1 episode)
Dan Gilvary
as Priest (1 episode)
Justin Tinucci
as Bully (1 episode)
Tania Gunadi
as Sarah (1 episode)
Tiago Roberts
as Bachelor (1 episode)
Sam Lazarus
as Reporter (1 episode)
Arthur Keng
as Waiter (1 episode)
Jamila Webb
as Kelly (1 episode)
April Adams
as Mavis (1 episode)
Freedom Bridgewater
as Delivery Guy (1 episode)
Alfred Adderly
as EMT (1 episode)
For the best insights and data about the TV show A.P. Bio, visit our main A.P. Bio page.