Cast of A.P. Bio

Glenn Howerton portrays Jack Griffin, a former Harvard professor who is forced to teach AP Biology at Whitlock High School. Jack is a sarcastic and self-absorbed character who initially uses his position to further his own selfish agenda.

Lyric Lewis plays the role of Stef, one of Jack's colleagues at Whitlock High School. Stef is a determined and passionate teacher who genuinely cares about her students' well-being and often finds herself trying to prevent Jack's schemes.

Mary Sohn portrays the character of Mary, another teacher at Whitlock High School. Mary is a kind-hearted and slightly naive teacher who is known for her cheerfulness and optimism, despite the chaos that often surrounds her.

Jean Villepique plays Michelle, the art teacher at Whitlock High School. Michelle is an eccentric and free-spirited character who often finds herself caught up in Jack's unconventional plans and schemes.

Tom Bennett portrays Miles, an enthusiastic and quirky teacher at Whitlock High School. Miles is known for his unorthodox teaching methods and his unique perspectives on various subjects.

Patton Oswalt plays Principal Durbin, the head of Whitlock High School. Principal Durbin is an awkward and often overwhelmed character who is constantly trying to maintain control over his school in the face of Jack's antics.

Aparna Brielle portrays Sarika, one of Jack's students at Whitlock High School. Sarika is a motivated and ambitious student who is often caught between her loyalty to Jack and her desire to succeed academically.

Sari Arambulo plays the character of Grace, another student at Whitlock High School. Grace is a charismatic and outgoing student who often finds herself swept up in the chaos and adventures that Jack brings into their lives.