Mr. & Mrs. Smith (TV) Cast
The cast of Mr. & Mrs. Smith. Updated on October 7, 2025.
80 actors
Donald Glover
as John Smith (8 episodes)

Donald Glover portrays John Smith, a highly skilled assassin and one half of the married couple. Glover is known for his roles in Community and Atlanta.

Maya Erskine
as Jane Smith (8 episodes)

Maya Erskine plays the role of Jane Smith, the other half of the skilled assassin married couple. Erskine is recognized for her work in PEN15 and Plus One.

Mark Eydelshteyn
as John Smith 0
Sophie Thatcher
as Jane Smith 0
Paul Dano
as Hot Neighbor (3 episodes)

Paul Dano assumes the character of [Character Name], a pivotal role in the series. Dano is celebrated for his performances in There Will Be Blood and Little Miss Sunshine.

Alexander Skarsgård
as Other John (1 episode)
John Turturro
as (1 episode)

John Turturro portrays [Character Name], adding depth to the show with his nuanced portrayal. Turturro is known for his roles in The Night Of and The Big Lebowski.

Tamara Torres
as Marla (1 episode)
Caleb Hearon
as Uber Driver (voice) (1 episode)
Eiza González
as Other Jane (1 episode)
Cavan Rogers
as Ticket Taker (1 episode)
Steven Weiss
as Ticket Taker 2 (1 episode)
Aki Ando
as Older Lady (1 episode)
Angela Chew
as Cashier (1 episode)
Candy Dato
as Violet (1 episode)
Michelle Concha
as Kitchen Chef (1 episode)
Lauren B. Martin
as Garden Party Host (1 episode)
Michael Egues
as Busboy (1 episode)
Michael Di Liberto
as Waiter (1 episode)
Ralphy Lopez
as Marla's Boyfriend (1 episode)
Siobhàn Aisling Carroll
as Hostess (1 episode)
Moti Margolin
as Mechanic (1 episode)
Eric Michael Gillett
as James Tyrone (1 episode)
Leslie Lynn Meeker
as Mary Tyrone (1 episode)
Lisa Dennett
as Neighbor 1 (1 episode)
Alexander Blaise
as Auction Party Host (1 episode)
Jaden Tolliver
as Valet (1 episode)
Nina Toussaint-White
as Auction Receptionist (1 episode)
Alicia Harding
as Nosy Woman (1 episode)
Orlando Cintron Jr.
as Caterer 1 (1 episode)
Campbell Symes
as Random Party Goer (1 episode)
Deegee Brandemour
as Lipstick Woman (1 episode)
Kristin Quinn
as Elegant Woman (1 episode)
Olvera Rodríguez
as Russ & Daughters Cashier (1 episode)
Sharon Horgan
as Gavol Martin (1 episode)
Billy Campbell
as Parker Martin (1 episode)
Dominic Raacke
as Tom (1 episode)
Eva Holzapfel
as Rita (1 episode)
Aaron Kane
as Graham (1 episode)
Andrea Mastrotto
as Bartender (1 episode)
Davide Enea Casarin
as Mountain Worker (1 episode)
Tiziano Carnevale
as Jasper (1 episode)
Claudio Pacifico
as Horace (1 episode)
Michele Ferrero
as Cable Car Operator (1 episode)
Parker Posey
as Other Jane (2 episodes)
Úrsula Corberó
as Rooney (1 episode)
David Fierro
as Juice Man (1 episode)
Wagner Moura
as Other John (2 episodes)
Chinara Stroman
as Juice Girl (1 episode)
Cindy Jackson
as Farmer (1 episode)
Legend Glover
as Benjamin (1 episode)
Marco Dzul
as Salvadorian Man (1 episode)
Alexis Anzola Castañeda
as Teenager (1 episode)
Clement Dávila
as Teenager (1 episode)
Edwing Del Angel
as Teenager (1 episode)
Emi "Jou" Hernandez
as Teenager (1 episode)
Israel Castillo Guzmán
as Teenager (1 episode)
Ivan Vazquez
as Teenager (1 episode)
Jorge Abraham Reyes Perez
as Teenager (1 episode)
Karina Nadia
as Teenager (1 episode)
Ron Perlman
as Toby Hellinger (1 episode)
Martinus Tocchi
as Fisherman (1 episode)
Livia Massimi
as Fisherwoman (1 episode)
Antonio Nicolai
as Fisherman's Child (1 episode)
Lucia Ricalzone
as Grandma (1 episode)
Maurizio Tabani
as Grandpa (1 episode)
Luisa Borini
as Mom (1 episode)
Moise Morancy
as Rodrick (1 episode)
Dontae Hawkins
as Terrence (1 episode)
Rell Battle
as Bucket (1 episode)
Sarah Paulson
as Therapist (1 episode)
Alex Huynh
as Seedy Man (1 episode)
Magnus Newville
as Therapist's Son (1 episode)
Mark Vincent
as Zombie Neighbor (1 episode)
Dave Attell
as Kosher Food Mart Clerk (1 episode)
Beverly Glover
as John's Mom (2 episodes)
Michaela Coel
as Bev (1 episode)
Amanda Kristin Nichols
as Woman in Subway (1 episode)
Leroy Powell
as Restaurant Owner (1 episode)
Danny Hilt
as Bystander (1 episode)
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