Kurt Russell plays Stephen McCaffrey, a seasoned firefighter and elder brother of Brian.
William Baldwin portrays Brian McCaffrey, the younger brother who joins the fire department despite family tensions.
Robert De Niro appears as Donald Rimgale, an investigator on the trail of an arsonist plaguing the city.
Donald Sutherland plays Ronald Bartel, a mysterious and wealthy industrialist tied to the fires in the city.
Jennifer Jason Leigh stars as Jennifer Vaitkus, a paramedic involved with one of the firefighters.
Scott Glenn portrays John 'Axe' Adcox, a veteran firefighter and mentor to the McCaffrey brothers.
Rebecca De Mornay takes on the role of Helen McCaffrey, the estranged wife of one of the firefighters.
Jason Gedrick portrays Tim Kirzminski, a young firefighter navigating the dangers of the job.
J.T. Walsh plays Alderman Marty Swayzak, a politician entangled in the corruption tied to the fires.
Anthony Mockus Sr. appears as Chief John Fitzgerald, the authoritative head of the fire department.
Cedric Young takes on the role of Grindle, a fellow firefighter within the force.
Juan Ramírez plays Ray Santos, a dedicated member of the firefighting team.
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