Martin Lawrence plays Marcus Burnett, one of the two narcotics detectives in Miami who is more cautious and family-oriented compared to his partner Mike Lowrey.
Will Smith portrays Mike Lowrey, the confident and charismatic Miami narcotics detective who is Marcus Burnett's partner.
Téa Leoni stars as Julie Mott, a witness to a crime who seeks the help of Marcus Burnett and Mike Lowrey for protection.
Tchéky Karyo plays Fouchet, the main antagonist in the film who leads a criminal organization involved in the narcotics trade.
Joe Pantoliano portrays Captain Howard, the police captain who oversees the work of Marcus Burnett and Mike Lowrey.
Theresa Randle appears as Theresa Burnett, Marcus Burnett's wife who supports him in his work as a detective.
Marg Helgenberger plays Alison Sinclair, a police officer and love interest of Marcus Burnett.
Nestor Serrano portrays Detective Sanchez, a member of the Miami narcotics team alongside Marcus Burnett and Mike Lowrey.
Julio Oscar Mechoso appears as Detective Ruiz, another member of the Miami narcotics team led by Marcus Burnett and Mike Lowrey.
Saverio Guerra plays Chet The Doorman, a character who assists Marcus Burnett and Mike Lowrey in their investigation.
Anna Thomson portrays Francine Donne, a friend of Julie Mott who gets caught up in the dangerous events unfolding in the film.
Kevin Corrigan appears as Elliot, a computer hacker who provides valuable assistance to Marcus Burnett and Mike Lowrey in solving the case.
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