Richard Dreyfuss plays Roy Neary, an electric lineman who experiences a close encounter with a UFO and becomes obsessed with uncovering the truth.
François Truffaut portrays Claude Lacombe, a French scientist leading the investigation into the UFO phenomena and seeking communication with extraterrestrial life.
Teri Garr plays Ronnie Neary, the wife of Roy Neary, who struggles to understand her husband's unusual behavior following his encounter.
Melinda Dillon takes on the role of Jillian Guiler, a mother searching for her son after he is abducted by aliens.
Bob Balaban plays David Laughlin, an assistant to Claude Lacombe who supports the scientific research into the UFO sightings.
J. Patrick McNamara is the Project Leader, overseeing military efforts related to the UFO incidents.
Warren J. Kemmerling portrays Wild Bill, a truck driver who also experiences a close encounter with the alien phenomenon.
Roberts Blossom plays the Farmer, a local farmer who witnesses UFO activity in his area.
Phil Dodds acts as the ARP Musician, involved in the musical communication methods with the extraterrestrials.
Cary Guffey plays Barry Guiler, Jillian's young son who is abducted by aliens during the film's events.
Shawn Bishop portrays Brad Neary, the son of Roy and Ronnie Neary who deals with the effects of the family's turmoil.
Adrienne Campbell plays Sylvia Neary, a family member supporting Roy's conflicted experience after his close encounter.
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