Rufus Sewell portrays the main character, John Murdoch, who wakes up in a hotel room with no memory of who he is or how he got there.
William Hurt plays Inspector Frank Bumstead, a detective investigating a series of mysterious murders in the city.
Kiefer Sutherland takes on the role of Dr. Daniel P. Schreber, a man with knowledge about the city's secrets who helps John unlock the truth.
Jennifer Connelly stars as Emma Murdoch, John's wife, who becomes a key figure in his quest to uncover the mysteries of Dark City.
Richard O'Brien portrays Mr. Hand, a sinister figure who is part of the group responsible for manipulating the city and its inhabitants.
Ian Richardson appears as Mr. Book, a member of the mysterious group controlling the city and its inhabitants.
Bruce Spence takes on the role of Mr. Wall, another member of the enigmatic group that manipulates reality in Dark City.
Colin Friels plays Det. Eddie Walenski, a detective who uncovers crucial clues about the city's true nature and its inhabitants.
John Bluthal portrays Karl Harris, a resident of Dark City who becomes entangled in John's journey towards discovering the truth.
Mitchell Butel appears as Officer Husselbeck, a law enforcement officer in the city caught up in the unfolding mystery.
Melissa George plays May, a woman with a mysterious connection to John Murdoch and his past in Dark City.
Frank Gallacher portrays Chief Inspector Stromboli, a high-ranking official who plays a pivotal role in the unfolding events in Dark City.
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