Dan Aykroyd plays the dual role of Clifford Skridlow, a mild-mannered professor, and Doctor Detroit, a wild and savvy pimp with a heart of gold.
Howard Hesseman portrays Smooth Walker, a sleazy and conniving mobster who clashes with Doctor Detroit.
Donna Dixon stars as Monica McNeil, a beautiful and intelligent woman caught up in the chaotic world of Doctor Detroit.
Lydia Lei plays Jasmine Wu, a fiery and independent woman who adds sparks to the storyline.
T.K. Carter portrays Diavolo Washington, a streetwise hustler and loyal ally of Doctor Detroit.
Lynn Whitfield shines as Thelma Cleland, a strong and supportive friend of Clifford Skridlow.
Fran Drescher brings humor to the screen as Karen Blittstein, a quirky and flirtatious character in the mix.
Kate Murtagh plays Mom, a maternal figure who provides guidance and wisdom to the characters.
Nan Martin appears as Margaret Skridlow, the mother of Clifford Skridlow, adding a touch of family drama to the story.
George Furth is Arthur Skridlow, the brother of Clifford Skridlow, bringing his own dynamics to the plot.
Peter Elbling portrays Guptor, a quirky and eccentric character who adds humor to the movie.
John A. Maloney plays Commodore, a serious and imposing figure within the world of Doctor Detroit.
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