Christina Applegate plays Swell, the rebellious teenage protagonist who must step up and take care of her siblings when the babysitter passes away.
Joanna Cassidy portrays Rose Lindsey, Swell's absent-minded mother who leaves her in charge of the family in her absence.
John Getz takes on the role of Gus, Swell's absent father who is oblivious to the chaos that ensues at home while he is away.
Josh Charles plays Bryan, Swell's older brother who initially enjoys the freedom of having no adult supervision.
Keith Coogan portrays Kenny, Swell's lazy and irresponsible brother who adds to the challenges she faces in running the household.
Concetta Tomei plays Mom, the character who hires the ill-fated babysitter and leaves Swell in charge of her siblings.
David Duchovny takes on the role of Bruce, an executive who becomes Swell's boss during her unexpected foray into the workforce.
Kimmy Robertson portrays Cathy, Swell's quirky coworker who befriends her at her new job.
Jayne Brook plays Carolyn, Swell's no-nonsense boss who challenges her to rise to the occasion in her new role.
Eda Reiss Merin takes on the role of Mrs. Sturak, a demanding client who Swell must impress during her unexpected career.
Robert Hy Gorman portrays Walter, one of Swell's younger siblings who she must care for in the absence of responsible adults.
Danielle Harris plays Melissa, another one of Swell's younger siblings who relies on her guidance after the babysitter's unexpected demise.
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