Dennis Quaid plays Willis Davidge, a human soldier who forms an unlikely bond with his alien enemy on the hostile planet.
Louis Gossett Jr. portrays Jeriba 'Jerry' Shigan, an alien from a reptilian species who becomes Davidge's unlikely ally and friend.
Brion James appears as Stubbs, a fellow human soldier who initially distrusts the alien but later comes to respect him.
Richard Marcus takes on the role of Arnold, another human soldier caught in the conflict between Davidge and the alien.
Carolyn McCormick plays Morse, a character who has a significant impact on the story as events unfold on the alien planet.
Lance Kerwin portrays Joey Wooster, a character who plays a role in the human-alien dynamics on the hostile planet.
Bumper Robinson voices the character Zammis, an important figure in the alien society who crosses paths with Davidge.
Jim Mapp appears as Old Drac, an elder member of the alien species who imparts wisdom and understanding to Davidge.
Scott Kraft takes on the role of Jonathan, a character who contributes to the unfolding story on the planet where Davidge and the alien are stranded.
Lou Michaels portrays Wilson, a character who adds to the dynamics of the human-alien interactions in the film.
Andy Geer appears as Bates, a character who plays a part in the tense relationships between the human characters in 'Enemy Mine'.
Henry Stolow portrays Cates, a character in the film who is involved in the challenging situations faced by the human soldiers.
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