Matthew Broderick portrays Ferris Bueller, a charismatic high school student who concocts elaborate schemes to skip school and have fun.
Alan Ruck plays Cameron Frye, Ferris's best friend who is more cautious and nervous than Ferris, but eventually loosens up during their day off.
Mia Sara portrays Sloane Peterson, Ferris's girlfriend who joins him and Cameron on their adventures throughout the day.
Jeffrey Jones takes on the role of Ed Rooney, the high school principal who is determined to catch Ferris skipping school and goes to great lengths to do so.
Jennifer Grey plays Jeanie Bueller, Ferris's overachieving and frustrated sister who becomes entangled in the events of Ferris's day off.
Cindy Pickett portrays Katie Bueller, Ferris and Jeanie's mother who is unaware of Ferris's scheming and is busy with her own responsibilities.
Lyman Ward plays Tom Bueller, Ferris and Jeanie's father who is also unaware of Ferris's antics as he goes about his day.
Edie McClurg portrays Grace, the school secretary who is manipulated by Ferris when he calls in pretending to be Sloane's father.
Charlie Sheen appears as the Boy in the Police Station, a seemingly tough character whom Jeanie encounters when she goes to report Ferris to the authorities.
Ben Stein plays the Economics Teacher, known for his iconic monotone delivery and the classic line 'Bueller... Bueller... Bueller...' during attendance.
Del Close portrays the English Teacher, who becomes exasperated with his students' lack of interest in literature and language.
Virginia Capers appears as Florence Sparrow, a nurse at the hospital where Ed Rooney ends up after a series of misadventures.
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