Ice Cube plays Craig Jones, the main protagonist who has recently lost his job and spends the day with his friend Smokey.
Chris Tucker portrays Smokey, Craig's best friend and a marijuana smoker who gets into trouble with a drug dealer.
Nia Long plays Debbie, Craig's love interest and neighbor who provides him with emotional support.
Tommy Lister Jr. portrays Deebo, the neighborhood bully who terrorizes the residents of South Central.
John Witherspoon plays Mr. Jones, Craig's father who provides comedic relief throughout the film.
Anna Maria Horsford portrays Mrs. Jones, Craig's no-nonsense and loving mother.
Regina King plays Dana Jones, Craig's sister who is protective of her family and provides a strong female presence.
Paula Jai Parker portrays Joi, a neighborhood girl who flirts with Craig and causes tension between him and Debbie.
Faizon Love plays Big Worm, a drug dealer who threatens Smokey and Craig over a drug deal gone wrong.
DJ Pooh portrays Red, a neighborhood friend of Craig and Smokey who gets caught up in their misadventures.
Angela Means plays Felisha, a neighbor who constantly annoys Craig and Smokey by asking to borrow things.
Vickilyn Reynolds portrays Joann, a neighbor who provides comic relief and is part of the local community in South Central.
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