Jean Reno portrays the titular character Léon Montana, a professional hitman with a complicated but fascinating life story.
Natalie Portman plays Mathilda Lando, a young girl who forms an unusual and poignant bond with Léon after a tragic event.
Gary Oldman embodies the role of Norman Stansfield, a corrupt and unhinged DEA agent with a penchant for violence.
Danny Aiello brings depth to the character of Tony, Léon's kind-hearted and supportive neighbor and friend.
Peter Appel plays Malky, a member of a criminal group who becomes entangled in the events surrounding Léon and Mathilda.
Michael Badalucco appears as Mathilda's Father, a troubled and neglectful figure in Mathilda's life.
Ellen Greene takes on the role of Mathilda's Mother, a vulnerable and somewhat distant parent in the film.
Elizabeth Regen plays Mathilda's Sister, a minor character in the narrative who has a small but impactful role.
Carl J. Matusovich portrays Mathilda's Brother, another minor character in the film who adds to the family dynamic.
Eric Challier appears as Bodyguard Chief, a character connected to the criminal underworld depicted in the movie.
Willi One Blood plays 1st Stansfield Man, one of the operatives in Norman Stansfield's corrupt and violent team.
Don Creech portrays 2nd Stansfield Man, another member of Norman Stansfield's dangerous group in the film.
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