Rick Moranis portrays Danny O'Shea, a kind-hearted gas station owner who becomes the coach of the underdog pee-wee football team.
Ed O'Neill plays Kevin O'Shea, Danny's competitive brother and rival coach of the elite pee-wee football team.
Devon Sawa stars as Junior Floyd, a former football star who comes back to town and joins the Giants.
Shawna Waldron takes on the role of Becky 'Icebox' O'Shea, Danny's daughter who is a talented football player.
Todd Bosley portrays Jake Berman, one of the lovable misfits who make up the Little Giants football team.
Michael Zwiener plays Rudy Zolteck, a member of the team who shows determination and heart on the field.
Danny Pritchett portrays Tad Simpson, a young player on the Giants who is enthusiastic about the game.
Troy Simmons plays Rashid Hanon, a member of the team known for his speed and quick moves on the field.
Sam Horrigan takes on the role of Spike Hammersmith, a player on the opposing team who is the Giants' main rival.
Joey Simmrin plays Sean Murphy, a member of the Giants and an essential part of the team's dynamic.
Marcus Toji portrays Marcus, one of the young players on the Little Giants team who brings his unique skills to the game.
Christopher Walberg plays Timmy Moore, a member of the team who learns valuable lessons about teamwork and perseverance.
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