Rick Moranis plays Seymour Krelborn, a kind but nerdy florist who discovers and nurtures a bloodthirsty plant named Audrey II.
Ellen Greene portrays Audrey, a kind-hearted but mistreated employee at Mushnik's Skid Row Florists and Seymour's love interest.
Vincent Gardenia takes on the role of Mr. Mushnik, the grumpy and opportunistic owner of Mushnik's Skid Row Florists where Seymour works.
Levi Stubbs provides the voice for Audrey II, the villainous and carnivorous plant with a powerful and manipulative presence.
Steve Martin plays Orin Scrivello, DDS, a sadistic and abusive dentist who is Audrey's violent and narcissistic boyfriend.
Tichina Arnold appears as Crystal, one of the streetwise and sassy members of the Greek Chorus trio that narrates the story.
Michelle Weeks portrays Ronnette, a member of the Greek Chorus trio that provides commentary and musical numbers throughout the film.
Tisha Campbell plays Chiffon, a member of the Greek Chorus trio that sings and interacts with the main characters in the movie.
Jim Belushi appears as Patrick Martin, a radio host who reports on Audrey II's growing fame and impact on the city.
John Candy takes on the role of Wink Wilkinson, a friendly but unfortunate radio broadcast executive who meets a dramatic end.
Christopher Guest plays The First Customer, a hapless and unwitting man who falls victim to Audrey II's insidious appetite.
Bill Murray portrays Arthur Denton, a masochistic patient who enjoys his visits to the sadistic dentist Orin Scrivello.
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