Robert De Niro portrays Wayne 'Mad Dog' Dobie, a mild-mannered crime scene photographer who saves the life of a mob boss, leading to a unique bond forming between them.
Uma Thurman plays Glory, a captivating barroom singer who becomes romantically involved with both Mad Dog and the mob boss, adding complexity to their intertwined relationships.
Bill Murray takes on the role of Frank Milo, a quirky mob boss who forms an unexpected friendship with Mad Dog after the latter saves his life, leading to a series of unpredictable events.
David Caruso portrays Mike, a member of Frank Milo's criminal organization who becomes suspicious of Mad Dog's sudden involvement in their affairs, adding tension to the group dynamic.
Mike Starr plays Harold, a loyal member of Frank Milo's crew who is protective of his boss and wary of Mad Dog's presence and influence within their criminal circle.
Tom Towles portrays Andrew the Beater, a menacing enforcer working for Frank Milo who harbors suspicions about Mad Dog's intentions and his relationship with the mob boss.
Kathy Baker takes on the role of Lee, a supportive friend of Mad Dog who offers him advice and guidance as he navigates the unexpected friendship with Frank Milo and the complexities that arise.
Derek Anunciation plays Shooter, a member of Frank Milo's crew who is wary of Mad Dog's presence and the potential threats it may pose to their criminal operations, leading to escalating tensions.
Doug Hara portrays the Driver, a minor character in the film who is involved in the criminal activities orchestrated by Frank Milo and interacts briefly with Mad Dog during key moments in the story.
Evan Lionel plays the Dealer in Car, a small-time criminal who crosses paths with Mad Dog and becomes entangled in the unpredictable events unfolding between the photographer and the mob boss.
Anthony Cannata portrays Pavletz, a background character in the criminal underworld depicted in the film who has brief interactions with key players like Mad Dog, Frank Milo, and their associates.
J.J. Johnston plays Shanlon, a minor character in the movie who is connected to the criminal activities orchestrated by Frank Milo, adding depth to the underworld portrayed in Mad Dog and Glory.
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