Woody Allen plays Isaac Davis, a neurotic and insecure television comedy writer grappling with his relationships and career.
Diane Keaton portrays Mary Wilkie, Isaac's intellectual and witty romantic interest.
Michael Murphy takes on the role of Yale, Isaac's best friend who has an affair with Mary.
Mariel Hemingway plays Tracy, a young and naive girl whom Isaac starts a relationship with.
Meryl Streep appears as Jill, Isaac's ex-wife who is writing a tell-all book about their marriage.
Anne Byrne Hoffman portrays Emily, Isaac's friend who organizes the opera event in the film.
Karen Ludwig plays Connie, a friend of Isaac's who is having an affair with Yale.
Michael O'Donoghue appears as Dennis, a close friend of Isaac who is a misanthrope and has a dark sense of humor.
Gary Weis portrays the Television Director in the film.
Kenny Vance appears as the Television Producer in Manhattan.
Tisa Farrow plays a Party Guest in the movie.
Damion Sheller appears as Ike's Son in a small role in the film.
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