Tom Arnold portrays Lt. Cmdr. Quinton McHale, the unconventional and resourceful leader of the crew.
Dean Stockwell takes on the role of Capt. Wallace B. Binghampton, the strict and rule-abiding commanding officer.
Debra Messing plays Lt. Penelope Carpenter, a smart and capable member of the crew.
David Alan Grier portrays Ensign Charles Parker, a rookie naval officer.
Bruce Campbell brings Virgil to life, a loyal and skilled crew member.
French Stewart plays Happy, a quirky and enthusiastic crew member.
Tim Curry portrays Maj. Vladikov, a flamboyant and sinister adversary.
Ernest Borgnine appears as Admiral Quinton McHale Sr., the father of Tom Arnold's character.
Danton Stone takes on the role of Gruber, a member of the crew with a mischievous streak.
Brian Haley plays Christy, a crew member known for his laid-back attitude.
Henry Cho portrays Willie, a member of the crew known for his comedic timing.
Tommy Chong portrays Armando/Ernesto, a dual role showcasing his comedic talents.
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