Patrick Swayze plays Truman Gates, a tough Chicago cop who seeks justice for his murdered brother.
Liam Neeson portrays Briar Gates, Truman's cousin and a key figure in the family's quest for vengeance.
Adam Baldwin appears as Joey Rosselin, a friend of the Gates family who aids in their mission for retribution.
Helen Hunt takes on the role of Jessie Gates, a member of the Gates family who becomes embroiled in the violent conflict.
Ted Levine plays Willy Simpson, a dangerous criminal linked to the murder that sets off the Gates family's quest for payback.
Bill Paxton portrays Gerald Gates, another member of the Gates family seeking justice for the loss they have suffered.
Michael J. Pollard appears as Harold, a character involved in the unfolding events alongside the Gates family.
Andreas Katsulas portrays John Isabella, a key figure in the criminal underworld of Chicago that the Gates family must navigate.
Del Close plays Frank, a character with ties to the criminal elements that the Gates family must confront.
Valentino Cimo appears as Rhino, a member of the criminal underworld linked to the events that spark the conflict in Next of Kin.
Paul Greco takes on the role of Leo, a character caught up in the violent clash between the Gates family and their adversaries.
Vincent Guastaferro portrays Paulie, a character entangled in the dangerous world that the Gates family must navigate in their pursuit of justice.
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