Steve Martin portrays Neal Page, a high-strung marketing executive trying to get home for Thanksgiving.
John Candy plays Del Griffith, a shower curtain ring salesman with a big heart and an even bigger personality.
Laila Robins takes on the role of Susan Page, Neal's wife who eagerly awaits his return home.
Michael McKean appears as the State Trooper who encounters Neal and Del on their chaotic journey.
Dylan Baker is Owen, an unhelpful airport employee who adds to Neal's frustrations.
Kevin Bacon has a cameo as the Taxi Racer who competes with Neal in a hilarious race to the train station.
Olivia Burnette plays Marti Page, Neal's daughter who eagerly prepares for Thanksgiving.
Carol Bruce portrays Joy Page, Neal's mother who anxiously awaits his arrival.
Diana Douglas appears as Peg, a car rental agent who clashes with Neal.
Martin Ferrero is the hapless Motel Clerk who witnesses Neal and Del's antics.
Larry Hankin plays Doobie, a bus passenger who interacts with Neal and Del during their journey.
Richard Herd is Walt, a fellow traveler who adds to the chaos of Neal and Del's trip.
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