Jane Fonda plays the character of Iris Estelle King, a woman working to support her family while facing personal challenges.
Robert De Niro portrays the role of Stanley Everett Cox, a widower who develops a meaningful connection with Iris while dealing with his own past.
Swoosie Kurtz plays Sharon, a supportive friend of Iris.
Martha Plimpton portrays Kelly King, Iris's daughter.
Jamey Sheridan plays Joe, a co-worker of Iris who supports her.
Feodor Chaliapin Jr. portrays Leonides Cox, Stanley's father.
Zohra Lampert plays Elaine, Stanley's sister.
Loretta Devine portrays Bertha, a friend of Iris.
Kathy Kinney plays Bernice, a co-worker of Iris.
Harley Cross portrays Richard King, Iris's son.
Julie Garfield plays Belinda, a friend of Iris.
Karen Ludwig portrays Melissa, a co-worker of Iris.
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