Josh Hartnett plays Zeke Tyler, a rebellious student known for selling illicit substances to his classmates.
Elijah Wood portrays Casey Connor, a nerdy student who becomes an unexpected hero in the fight against the alien threat.
Clea DuVall takes on the role of Stokely 'Stokes' Mitchell, a goth student who initially keeps to herself but eventually becomes a key figure in the group's resistance.
Jordana Brewster plays Delilah Profitt, the school's popular and ambitious newspaper editor.
Shawn Hatosy portrays Stan Rosado, a member of the football team who finds himself fighting alongside a diverse group of students.
Laura Harris takes on the role of Marybeth Louise Hutchinson, a new student with a mysterious past that complicates the group dynamics.
Usher plays Gabe Santora, a student athlete who joins forces with his classmates to confront the alien threat.
Salma Hayek Pinault portrays Nurse Rosa Harper, a staff member at the school who becomes entangled in the unfolding chaos.
Robert Patrick plays Coach Joe Willis, a teacher and coach who must confront the alien threat while grappling with his own suspicions.
Famke Janssen portrays Miss Elizabeth Burke, a no-nonsense educator who becomes a crucial ally in the fight against the alien parasites.
Piper Laurie plays Mrs. Karen Olson, a teacher at the school who finds herself in the midst of a terrifying conspiracy.
Christopher McDonald portrays Mr. Frank Connor, a science teacher and Casey's father who becomes embroiled in the otherworldly events at the school.
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