Jennifer Aniston plays the character Nina Borowski, a social worker who forms a close bond with her gay friend George.
Paul Rudd portrays George Hanson, a gay first-grade teacher who becomes Nina's roommate and close confidante.
Alan Alda takes on the role of Sidney Miller, a seasoned and wise grandfather-like figure in George's life.
Nigel Hawthorne plays Rodney Fraser, a prestigious theatre actor who gets entangled in the characters' lives.
John Pankow portrays Vince McBride, George's boyfriend who complicates the dynamics of their relationships.
Tim Daly plays Dr. Robert Joley, a supportive physician who interacts with the characters during pivotal moments.
Allison Janney takes on the role of Constance Miller, Sidney's wife who adds another layer to the interconnected group.
Steve Zahn portrays Frank Hanson, George's brother who brings humor and familial dynamics to the storyline.
Amo Gulinello plays the character Paul James, adding depth to the ensemble cast of The Object of My Affection.
Bruce Altman portrays Dr. Goldstein, a supporting character who provides professional insight within the narrative.
Kevin Carroll plays Louis Crowley, introducing a unique perspective into the group dynamics of the characters.
Lauren Pratt portrays Sally Miller, adding a youthful and innocent energy to the interconnected relationships in the movie.
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