Woody Harrelson plays Dr. Michael Reynolds, a disillusioned oncologist who goes on a transformative journey after an encounter with a young Native American boy.
Talisa Soto portrays the Navajo Woman who impacts Dr. Reynolds' life during his road trip.
Anne Bancroft appears as Dr. Renata Baumbauer, a key figure in Dr. Reynolds' world.
Jon Seda takes on the role of Brandon 'Blue' Monroe, a character who plays a significant part in Dr. Reynolds' journey.
Alexandra Tydings is Victoria Reynolds, a character with ties to Dr. Reynolds.
Andrea Roth plays Head Nurse, a supporting character in the film.
Matt Mulhern portrays Dr. Chip Byrnes, a member of the medical team involved in Dr. Reynolds' story.
Richard Bauer appears as Dr. Bradford, another medical professional in the film.
Victor Aaron takes on the role of Webster Skyhorse, a character who adds depth to the story.
Lawrence Pressman plays Agent in Charge Collier, a figure involved in the unfolding events of the movie.
Michael O'Neill is Agent Moreland, another character in the movie.
Harry Carey, Jr. appears as Cashier, a minor character who contributes to the storyline.
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