Susan Sarandon portrays Jane Spofford, one of the three witches in the film.
Cher takes on the role of Alexandra Medford, a strong and independent witch.
Michelle Pfeiffer plays the character Sukie Ridgemont, another one of the powerful witches.
Jack Nicholson stars as Daryl Van Horne, the mysterious and charming man who disrupts the lives of the three witches.
Veronica Cartwright appears as Felicia Alden, a character affected by the supernatural events in the town.
Richard Jenkins plays Clyde Alden, a town resident impacted by the unfolding events involving the witches and Daryl Van Horne.
Keith Jochim portrays Walter Neff in the movie.
Carel Struycken takes on the role of Fidel in The Witches of Eastwick.
Helen Lloyd Breed appears as Mrs. Biddle in the film.
Caroline Struzik plays the character Carol Medford.
Michele Sincavage appears as Ridgemont Child.
Carole Ita White takes on the role of the Cashier in The Witches of Eastwick.
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