Check It Out! with Dr. Steve Brule (TV) Cast
The cast of Check It Out! with Dr. Steve Brule. Updated on October 7, 2025.
154 actors
John C. Reilly
as Dr. Steve Brule (24 episodes)

John C. Reilly plays Dr. Steve Brule, an unusual and often confused doctor exploring everyday subjects.

Atsushi Watanabe
as Sushi Chef (1 episode)
Jonny Bowden
as Self (1 episode)

Jonny Bowden appears as himself, contributing his expertise on nutrition.

Rod Davis
as (1 episode)
William Holt
as (1 episode)
Jose G. Lopez
as Janitor (1 episode)

Jose G. Lopez plays the Janitor, a character who interacts with Dr. Steve Brule in various episodes.

Julie O'Brien
as (1 episode)
Gloria Sandoval
as (1 episode)
Karon Stocking
as (1 episode)
Joji Yokoe
as (1 episode)
Don Davis
as Self (1 episode)

Don Davis appears as himself, bringing his music knowledge to the show.

Maria Bamford
as Cynthia Driscoll (1 episode)

Maria Bamford plays Cynthia Driscoll, a character who often crosses paths with Dr. Brule.

Bruce Eason
as (1 episode)
Ian Halstein
as (1 episode)
Nickolay Maleko
as (1 episode)
Melissa Manning
as (1 episode)
Liz Valente
as (1 episode)
Bob Baker
as Self (1 episode)
Scotty Castillo
as (1 episode)
Ursula Heinle
as Self (1 episode)
Sandy Sanders
as Self (1 episode)
Stephan D. Gill
as Steve Davis (1 episode)
Ann J. Elkin
as Dr. Davis (1 episode)
Elaine Ballace
as (1 episode)
Charles Bone
as (1 episode)
Susan Cottrell
as (1 episode)
Edward Diggsby
as (1 episode)
Manuel Fierro
as (1 episode)
Hunter Fox
as (1 episode)
Sandy Jeanphilippe
as (1 episode)
Fermin Lagunas
as (1 episode)
Kenny Lopez
as (1 episode)
Mark Malan
as (1 episode)
David Markey
as (1 episode)
Charles Matula
as (1 episode)
Dwayne Mosco
as (1 episode)
Wora Rapp
as (1 episode)
Jacinta Robert
as (1 episode)
Herman Rogue
as (1 episode)
Brent Sweet
as (1 episode)
Irma Thorn
as (1 episode)
Tiny Ron
as God (1 episode)
Brian Ventimiglia
as (1 episode)
Charles Villano
as (1 episode)
Scott Wisman
as (1 episode)
Yasmin Yas
as (1 episode)
Gary Lecroix
as Self (1 episode)
Ronnie Rodriguez
as Self (1 episode)
Dayna Allen
as (1 episode)
Linda Eaton
as (1 episode)
Charles Erickson
as (1 episode)
Regan Forston
as (1 episode)
Purita Wattanakulchotikarn
as Self (1 episode)
Ronald Barker
as Self (1 episode)
Paulette Hunnewell
as (1 episode)
Anthony Nguyen
as (1 episode)
Mauricio Solis
as Goon (1 episode)
Joe Zacharia
as (1 episode)
David Falk
as Self (1 episode)
David Jurasevich
as Self (1 episode)
Martin Faigin
as (1 episode)
Jolie Mason
as (1 episode)
Amy Porter
as (1 episode)
Sean Roach
as Self (1 episode)
Kelyan Ayachi
as (1 episode)
Aykut Bayrak
as Self (1 episode)
Rob Karlin
as (1 episode)
Sherri Smith
as Fertility clinic nurse (1 episode)
LeRoy Thompson
as (1 episode)
Donna Rusch
as Linda Barrelli (1 episode)
Amy Moorman
as (1 episode)
Darcy Vernier
as (1 episode)
Reuban Piranian
as (1 episode)
Daniel M. Hooper
as (1 episode)
Lydia Sims
as (1 episode)
Diamond
as (1 episode)
Oberon Zell
as Self (1 episode)
Michael O'Garro Jr.
as (1 episode)
Kevin Lee
as (1 episode)
Darin Rossi
as (1 episode)
Irving Orozco
as Self (1 episode)
Cheryl A. Smith
as Self (1 episode)
Rolando W. Wolovich
as Self (1 episode)
Bryan Heard Jr.
as (1 episode)
Laine Lasanta
as (1 episode)
Rhoen Reddy
as (1 episode)
Ryce Waker
as (1 episode)
David N. Alexander
as (1 episode)
Adora Dei
as Doctor (1 episode)
Gwen Holloway
as ER Doctor (1 episode)
Lindsay McGrail
as ER Nurse (1 episode)
June Mock
as Doctor (1 episode)
Ernest L. Moore
as (1 episode)
Bob Raynor
as Uncle Gary (2 episodes)
Ron Don Volante
as Self (4 episodes)
Bobby Javinett
as (1 episode)
Andy Mardrosian
as (1 episode)
Frank Vargas
as (1 episode)
Christine Dupree
as Girl in Dream (1 episode)
Sophiah Koikas
as Girl in Dream (1 episode)
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