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Rizzoli & Isles is an American crime drama television series based on the characters of a series of crime novels by Tess Gerritsen. The show follows the lives of Boston detective Jane Rizzoli and her best friend, medical examiner Dr. Maura Isles, as they work together to solve complex murder cases. With a combination of wit, intelligence, and strong chemistry between the two lead characters, Rizzoli & Isles captivates viewers with its engaging storylines and compelling performances.