Jeff Daniels portrays Dr. Ross Jennings, a city doctor who moves with his family to a small town and has to face a deadly spider infestation.
Harley Jane Kozak plays Molly Jennings, the supportive wife of Dr. Ross Jennings who also becomes entangled in the spider mayhem.
John Goodman takes on the role of Delbert McClintock, an eccentric and fearless exterminator hired to deal with the spider problem.
Julian Sands is Doctor James Atherton, an arachnologist who helps identify the deadly spider species causing havoc in the town.
Brian McNamara portrays Chris Collins, a local resident who teams up with Dr. Ross Jennings to combat the spider infestation.
Stuart Pankin plays Sheriff Lloyd Parsons, the town's skeptical sheriff who eventually has to confront the terrifying arachnid threat.
Henry Jones is Doctor Sam Metcalf, the town's elderly doctor who witnesses the spider-related deaths and tries to help the community.
Peter Jason portrays Henry Beechwood, a local resident who falls victim to the deadly spiders, sparking further fear in the town.
Mark L. Taylor plays Jerry Manley, a character who experiences the deadly consequences of the spider infestation firsthand.
James Handy portrays Milton Briggs, a town resident who faces the deadly spiders and adds to the growing panic in the community.
Roy Brocksmith is Irv Kendall, a town resident caught up in the chaos of the spider invasion, adding to the tension and horror.
Kathy Kinney plays Blaire Kendall, a character who must confront the deadly spiders alongside her fellow townspeople, facing intense peril.
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