Paul Dillon plays the main character, Cab Driver, who encounters a range of passengers while driving his cab through Chicago.
Michael Ironside portrays Al, one of the passengers who gets into the cab and engages in a conversation with the Cab Driver.
Laurie Metcalf takes on the role of Female Ad Exec, a passenger who shares her perspective with the Cab Driver during the ride.
John C. Reilly plays Steve, another passenger who interacts with the Cab Driver during a part of the journey.
Gillian Anderson appears as Southside Girl, a passenger with a unique story to tell during her ride in the cab.
John Cusack portrays Scary Man, a passenger whose presence brings a different energy to the cab ride.
Julianne Moore takes on the role of Distraught Woman, a passenger who shares her emotional turmoil with the Cab Driver.
Moira Sinise portrays Religious Mother, a passenger who engages in a deep conversation with the Cab Driver during the ride.
Darryl Theirse plays X-Hat, a character with a unique style and perspective who interacts with the Cab Driver.
Shanésia Davis portrays Lawyer, a passenger who brings a legal perspective into the conversation with the Cab Driver.
Matt Roth takes on the role of Male Ad Exec, a passenger who shares business insights during the cab journey.
Ron Dean appears as Old Snack Trucker, a passenger who adds a touch of nostalgia to the cab ride with his character.
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